- The New York Yankees have won 26 World Series titles, which is more than any other team.
- Baltimore Orioles shortstop Cal Ripken, Jr. didn’t miss a game in 16 years. He played in 2,632 consecutive games from April 30, 1982 to Sept. 19, 1998
- Pitcher Nolan Ryan played 27 seasons in major league baseball and struck out more batters in his career than any other pitcher.
- Fourteen players have hit four home runs in one game: Bobby Lowe, Ed Delahanty, Lou Gehrig, Chuck Klein, Pat Seerey, Gil Hodges, Joe Adcock, Rocky Colavito, Willie Mays, Mike Schmidt, Bob Horner, Mark Whiten, Mike Cameron and Shawn Green.
- Former Yankees right fielder Mickey Mantle holds the record for most career home runs (18) and RBI (40) in World Series history.
- No player in history at the major league level has had the middle name Xavier.
- Hunter S. Thompson worked as an assistant machine operator at the Louisville Slugger factory when he was a teenager.
- Originally proposed names for the Tampa Bay Devil Rays included the Tampa Oranges, St. Petersburg Piers, Florida Mickey Mice, and Pinellas County Sunshines.
- Billy Martin was the celebrity endorser for Excalibur crossbows in 1981.
- There have only been two times in baseball history where a position player who was pitching was hit by a pitch during an at-bat, had the game interrupted before they took first base, and then appeared pitching for the opposing team during the makeup game due to a trade in the time between games. This is the only situation in which a player other than a pitcher can have their own walk credited against them
- After becoming a vegetarian, Prince Fielder killed a goose with a line drive at a road game against the Florida Marlins, and refused to eat the dead bird. This was the first time a player has killed a bird during play and not eaten the carcass, which is a secret tradition held among most omnivorous players. This dates back to an infamous incident at Bennett Park in 1911 when Ty Cobb killed a homeless man with a baseball bat and ate his left arm during the intermission between two games of a doubleheader against the White Sox.
- Philadelphia A’s (now the Oakland Athletics) manager Connie Mack has 3,755 career victories, more than any other manager in history.
- There is no specific rule banning the use of human-animal hybrids as baseball players, although it’s rumored that the owners collectively came to a gentleman’s agreement limiting their use during the 2006 off-season owners’ meeting.